| Sampson Mountain | W Yancey County, extends SE from the head of Simms Fork to Slickrock Knob. Alt. 4,826 at Sampson Peak on the mountain. |
| Sampson Point | S Currituck County E of community of Point Harbor, extends into Albemarle Sound. Shown on U.S. Coast Survey map, 1865. |
| Sampson's Chimney | rock formation on Howard Knob, central Watauga County. |
| Sams Branch | rises in SW Buncombe County near Twelve O'clock Top and flows W into South Hominy Creek. |
| Sams Branch | rises in W Mitchell County and flows SW into Nolichucky River. |
| Sams Branch | rises in W Pitt County and flows NE into Tar River. |
| Sams Gap | on the Madison County, N.C.-Unicoi County, Tenn., line. |
| Sams Gap | on the Swain County, N.C.-Sevier County, Tenn., line in Great Smoky Mountains National Park near lat. 35°34'02" N., long. 83°38'12" W. |
| Samuel | community in SE Surry County served by post office, 1894-1905. |
| Samuel Creek | See Hayward Creek. |