| Saxapahaw River | See Haw River. |
| Saxon | community in E Stokes County served by post office, 1891-1912. |
| Scale Creek | rises in NE Onslow County and flows SW into Northeast Creek. |
| Scalesville | community in N Guilford County. Named for the Scales family of Guilford and Rockingham Counties. |
| Scaly Mountain | S Macon County between the head of Middle Creek and the head of Piney Knob Fork. Alt. 4,804. |
| Scaly Mountain | community in S Macon County on Middle Creek. |
| Scaly Ridge | SE Clay County between Tallulah River and Beech Creek. |
| Scapecat Branch | rises in S Haywood County and flows W into Little East Fork Pigeon River. |
| Scarboro | community in SW Montgomery County served by post office, 1880-1901. |
| Scarlet Ridge | N Swain County in Great Smoky Mountains National Park extending SE from Welch Ridge to Forney Creek. Near lat. 35°31'54" N., long. 83°34'40" W. |