| Sealeys Creek | See Celia Creek. |
| Searcy Creek | rises in W central Transylvania County and flows NE into Davidson River. |
| Seaside | community in SW Brunswick County. |
| Seay Mountain | central Haywood County between Jonathans Creek and Pigeon River. Alt. 3,358. |
| Secession | community in SW Brunswick County. |
| Seco | an Indian village shown on John White's map of 1585 located in what is now central Beaufort County. The name is associated with American discoveries dating from 1536, though located on different maps from the Chesapeake Bay S to Florida. De Bry's version of White's map, printed in 1590, changes Seco to Cotan. See also Secotan. |
| Second Broad River | rises in S McDowell County and flows SE into Rutherford County, which it crosses to the Cleveland County line and enters Broad River. |
| Second Creek | rises in W Randolph County and flows E into Uwharrie River. |
| Second Creek | rises in E Tyrrell County and flows SE into Alligator River. Called Third Creek on the Collet map, 1770. Approx. 4½ mi. long and ¾ mi. wide at its mouth. |
| Second Creek | rises in N central Tyrrell County S of community of Pleasant View and flows W into Scuppernong River approx. 2¾ mi. S of town of Columbia. An old Indian village of uncertain tribal affiliation, Mequopen, is shown at the mouth of the creek on the De Bry map, 1590. Name means "red tribes" or "where there are red tribes." |